• A comparative trial of disulfiram, naltrexone, and acamprosate in alcohol treatment

    Posted on July 23, 2013
    Past research suggests that (self-empowering addiction treatment) cognitive-behavioral therapy is effective in the treatment of alcohol dependence. In some cases, psychological treatment can be significantly improved by pharmacotherapy. Pharmacotherapies used in alcohol treatment include disulfiram, an aldehyde dehydrogenase inhibitor; naltrexone, an opioid antagonist; and acamprosate, a noncompetitive NMDA receptor blocker. Few studies have compared the effectiveness of these pharmacotherapies. A team of researchers from Finland set out to do just that (Laaksonen et. al., 2008). The researchers conducted a randomized, open label, multicenter naturalistic study in two phases. The first phase consisted of 12 weeks of continuously supervised medication. The second phase consisted of up...
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