Early Research on LSD for Alcohol Problems: A Look at State Mental Hospitals and Elsewhere By Kenneth Anderson, MA In the 1950s, researchers such as Humphry Osmond and Abram Hoffer in Saskatchewan, Canada developed a unique therapy for alcoholism which entailed using a psychedelic experience to alter the beliefs and values of the alcoholic patients. Set and setting were essential variables in successfully inducing a psychedelic experience. The term "set" refers to the internal mindset of the person about to undergo the psychedelic experience. Patients were given weeks of psychological preparation by the researchers before they were given LSD, in order to ensure that they had the proper mindset for a positive and life-altering psychedelic experience. The term "setting" referred to th...

By Kenneth Anderson, MA Is Moderate Drinking Protective Against Alzheimer's Disease? Brain Changes with Alzheimer's Disease Amyloid Beta Plaques We have known for more than a century that the brains of people with Alzheimer's disease are filled with amyloid beta plaques and neurofibrillary tangles. Moreover, the brains of people with Alzheimer's disease are severely atrophied due to the death of brain cells. Most researchers believe that the brain atrophy and death of brain cells found in Alzheimer's disease is due to the effects of amyloid beta plaques and neurofibrillary tangles, although many details about this process remain unclear. It is also unclear whether amyloid beta plaques and neurofibrillary tangles contribute equally to the death of brain cells or if one of these is th...

The Value of Advocating for Safer (But Not Reduced) Substance Use By Tom Horvath, PhD In a study recently published online, researchers at Brown University (a major US addiction research site) compared an intervention to reduce the drinking of heavy drinking college students (without focusing on the consequences of drinking), with an intervention to reduce the negative consequences from drinking (without focusing on the amount of drinking). Both interventions worked as predicted. The first group (PNF; Personalized Normative Feedback) reduced drinking (without reducing consequences) and the second group (CAA; Counter-Attitudinal Advocacy) reduced consequences (without reducing drinking). The subjects were 585 students who by self-report engaged in episodes of heavy drinking and ...

Neuronal Plasticity, Mindfulness Meditation, and Addiction Recovery by Nicholas A. Nelson, Ph.D. Part 2 of 2 In Part 1, we visited the motivations for leveraging mindfulness as a tool for overcoming problematic addictive behaviors. We discussed the concept of neuroplasticity and took a theoretical look at how mindfulness meditation can aid in reshaping our brain and behavior during addiction recovery. In Part 2 we’ll take a look at a few specific scientific studies that have put these theories to the test, then wrap up with a discussion of what mindfulness meditation can feel like in practice. Let’s dive in. The Frontal Lobe Because the neuroscience of addiction and neuroscience of meditation are rather complex and relatively new topics, they are still undergoing rapid...

by Tom Horvath, PhD There are many occupations considered to be safety-sensitive. The industries from which they are drawn include healthcare, transportation, and construction. Specific occupations include physicians, airline pilots, and heavy equipment operators. When these individuals have their substance use monitored (often because of recent substance problems), what principles should guide the creation of the monitoring plan? Let us focus on alcohol, because it may be the most common substance monitored. There are many methods to monitor alcohol use. They differ according to the timeframe they observe, their accuracy (will they miss use that occurred?), whether they assess the substance itself or a metabolite, the convenience of use (e.g., including how far one must go to get...

By Tom Horvath, PhD This article focuses on physicians with substance problems (and by extension all licensed professionals). However, the underlying idea, that those wanting to assist someone with substance problems should focus on ends not means, applies widely. In most US states there is a state-recognized Physician Health Plan (PHP) which often controls how physicians who have substance problems are dealt with. Similar plans exist for other licensed professionals. These organizations do much beneficial work. No one wants a licensed professional with substance problems. The national organization for PHPs is: https://www.fsphp.org, the Federation of State Physician Health Plans. In this article I focus on some major problems with PHPs (and the parallel organizations). The ide...

Neuronal Plasticity, Mindfulness Meditation, and Addiction Recovery by Nicholas A. Nelson, Ph.D. Part 1 of 2 It is not uncommon during active addiction or early in recovery for people to feel that their brain is working somehow differently than before, or to feel like it is going to be impossible to break out of harmful habits and thought patterns. It can feel like the mind is damaged, or operating out of our control. This lack of control, and feeling that something is broken, can lead to a sense of hopelessness. When we look at the brain there is some truth to this feeling - during engagement with problematic addictive behaviors and during early recovery, our brains are not wired in the same way as before these problems took root. Through months, years, or decades of repetiti...

by Kenneth Anderson, MA The National Institute on Alcohol Abuse and Alcoholism (NIAAA) defines binge drinking as drinking enough alcohol to reach a blood alcohol concentration (BAC) of 0.08% or higher, i.e., to become legally intoxicated. For men, this typically means drinking five or more US standard drinks in a two-hour period. For women, this is typically four or more standard drinks in a two-hour period. Extreme binge drinking, also known as high-intensity drinking, is defined as drinking enough alcohol to achieve a BAC of .16% or higher, in other words, drinking twice as much as the amount for regular binge drinking. Extreme binge drinking is associated with throwing up or passing out. In the United States, extreme binge drinking is a common occurrence at 21st birthday celebr...

Part Three from the Series: Does Alcohol Kill Brain Cells? Research on Clinical Samples by Kenneth Anderson, MA Stavro et al. (2013) conducted a review of clinical studies of cognitive impairments in people with alcohol use disorder (AUD) and their reversal with abstinence. IQ was found to be unaffected by AUD; there were no significant differences in IQ between people with AUD and control subjects. However, 11 other cognitive domains were moderately impaired in people with AUD: verbal fluency/language, speed of processing, working memory, attention, problem-solving/executive functions, inhibition/impulsivity, verbal learning, verbal memory, visual learning, visual memory, and visuospatial abilities. Cognitive impairments began to abate during the first month of abstinence from alc...

This week, Kenneth Anderson, MA, explores MRI and brain shrinkage research in part 2 of the series, "Does Alcohol Kill Braincells?" Part 1 can be found here. By Kenneth Anderson, MA A 2001 study by Kubota et al. performed MRIs on 1,432 employees and family members (1,061 men and 371 women) of a large Japanese corporation to investigate shrinkage of the frontal lobe of the brain. Subjects were each categorized by their drinking status (abstainers, light drinkers, moderate drinkers, heavy drinkers), age (30s, 40s, 50s, or 60s), and brain shrinkage (shrunken, not shrunken). Heavy drinkers were classified as those who drank 350 grams of ethanol (25 US standard drinks) or more per week. There were no significant differences between the abstainers, light drinkers, and moderate drinkers ...